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　　He presided over the design of the emblem and mascot "Fuwa" of the 2008 Beijing Olympic Games, and people affectionately called him "the father of Fuwa".

　　He was awarded the title of "Artist of Peace" by UNESCO, "Coubertin Award" by the International Olympic Committee, "Cultural Medal of the President of Korea" and "Honorary Academician" by the University of Venice.

　　He has four personal art galleries in Hangzhou, Beijing, Yinchuan and Yixing, and his works involve painting, calligraphy, sculpture, ceramics, design and many other aspects, and all thousands of works have been donated to the country for future generations to study.

　　His achievements in painting, calligraphy, sculpture, ceramics and other artistic fields have attracted worldwide attention. He is called "China’s Picasso" because of his wide cross-border, profound artistic attainments, distinctive personality and great social influence, but he claims to be "the successor of grandma in northern Shaanxi".

　　He is Mr. Han Meilin, a UNESCO peace artist, a senior professor of liberal arts in Tsinghua University and a professor at Tsinghua University Academy of Fine Arts.

Han Meilin

　　Born in Jinan, Shandong, China in 1936. In 1955, he was admitted to the Central Academy of Fine Arts (in 1956, he became the first student of the Central Academy of Arts and Crafts with the adjustment of departments). He is currently a senior professor of liberal arts in Tsinghua University, a librarian in central research institute of culture and history, honorary director of ceramic art committee of China Artists Association, vice president of World Chinese Association and honorary president of China Arts and Crafts Association.

　　In recent years, "Han Meilin Art Museum" has been established in Hangzhou, Beijing and Yinchuan, and "Han Meilin Zisha Art Museum" has been established in Yixing, actively promoting social aesthetic education and international cultural exchanges. Establish "Han Meilin Art Foundation" and devote yourself to artistic public welfare and social charity. In 2015, he was awarded the title of "Peace Artist" by UNESCO. 2016 "The World of Merrill Lynch • Han Meilin’s Global Tour was launched, and he held solo exhibitions in Venice, Beijing, Paris, Liechtenstein, Seoul and Bangkok, and was awarded the title of "Honorary Academician" by the University of Venice. In 2018, he won the "Coubertin" Medal and the "Korean Cultural Medal" of the International Olympic Committee. In 2019, he won the "Lifetime Achievement Award for Influencing the World Chinese Award".

　　Why did suffering make his life beautiful? Why is his life’s creation not the same? Where did his confidence come from? Why should artists learn to think independently about the world? Why do artists have to have great love?

　　On March 22nd, at 7: 00 pm, Mr. Han Meilin, a UNESCO peace artist, a senior professor of liberal arts in Tsinghua University and a professor of Tsinghua University Academy of Fine Arts, gave a special performance "Taking Heaven as a Painting", which took you into the wonderful art world of this master!

　　In the winter of 1936, Han Meilin was born in a family of four in Huangjinxiang, Jinan. His parents loved each other and lived with his grandmother who had been widowed for many years. Three generations lived happily in three tile houses in the alley. But the good times didn’t last long. My father died of tuberculosis two years later, leaving Han Meilin’s mother, two widows and three brothers who were not yet adults. At that time, the youngest brother was only born for more than a month. Two young widowed women resolutely shouldered the burden of life, helped each other to raise three children and never remarried. But even in such a difficult situation, two women in bad karma still attach importance to education and insist on sending their children to school.

　　When Han Meilin was five years old, his mother sent him to a private school to practice calligraphy. Mr. Wang found Han Meilin’s square and tough personality and thought that he was the most suitable for Yan Zhenqing, a famous minister in the Tang Dynasty. Since then, he has laid the foundation for Han Meilin’s calligraphy all his life. At the same time, he began to show his talent for painting. He painted on the wall of his neighbor’s house with lime, and was beaten by his mother for destroying the newly painted wall. A little longer, Han Meilin entered Jinan Authentic Relief Society Primary School for the Poor. The school was founded by famous gentry and wealthy businessmen who worked in Jinan. It not only exempted tuition fees, but also invited Li Yuanqing, Zhao Yuanren, Chen Shuliang, Qin Hongyun and other famous artists to offer sports, music, art and other stylistic courses for students. The school is not far from home. It is a rare beauty for Han Meilin to grab a handful of tea dregs poured out of the teahouse for breakfast on the way to school on foot. Compared with the lack of material life, the school’s aesthetic education has given Han Meilin the best enlightenment in his artistic life. He loves painting more, and his teachers affectionately call him a "little painter".

　　In 1948, Jinan ushered in liberation, and Han Meilin, who had just entered junior high school, decided to drop out of school to work to reduce the burden on his family. Shortly after the liberation of Jinan, the government planned to build a memorial tower for revolutionary martyrs on Sili Mountain in the south of the city. With the help of the Civil Affairs Department, Han Meilin, who was only 13 years old, became the correspondent of commander Wan Chunpu in the preparatory office. At that time, the relief group of the Tower Building Committee gathered a group of well-known domestic artists. Han Meilin, who was fascinated by painting since childhood, followed these artists for advice. Later, he was simply sent to the relief group by Commander Wan as a correspondent. He followed Wang Zhaoshan, Liu Su and Mud to make sculptures. In order to understand the human body structure, he made human skeleton specimens together with Xue Junlian. In the example of the artists, Han Meilin’s artistic level was rapidly improved.

Mr. Han Meilin, who just joined the army in the Tower Building Committee.

　　After the War to Resist U.S. Aggression and Aid Korea started, Han Meilin transferred to Jinan Repertory Theatre as an actor, and also volunteered to work part-time in the propaganda work of the troupe. Soon, the Repertory Theatre was dissolved, and Han Meilin was assigned by the Bureau of Culture and Education to serve as an art teacher in Nanchenggen Primary School in Jinan. At that time, Han Meilin was less than 15 years old, but he used his painting strength to subdue students about his own age, and also attracted primary school art teachers in the whole region to observe the teaching. At the beginning of the founding of the People’s Republic of China, new China was in ruins, and there was even a blank in primary school art education in China. Shandong People’s Publishing House came here to compile his lesson plans into two textbooks, Basic Knowledge of Painting and Reference Album of Primary School Painting Teaching. Han Meilin got 400 yuan for this. In that era when 10 cents could buy four eggs, this fee was a huge sum. Han Meilin used this money to buy gifts for his family and a bicycle for going out on weekends.

Mr. Han Meilin’s youth

　　Han Meilin’s passion for fine arts touched Li Shuhua, a Chinese teacher at the same school. He introduced Han Meilin to his cousin Le Wei, who was studying at Shanghai Academy of Fine Arts. With the encouragement of Le Wei, Han Meilin decided to apply for the middle school attached to Central Academy of Fine Arts. Newborn calves are not afraid of tigers. Han Meilin went to Beijing with enthusiasm to catch the exam. He was unexpectedly received by Mr. Pang Xunqin, the director of the Department of Arts and Crafts of the Academy of Fine Arts and a master figure in the art world. Mr. Pang saw the talent of this young man from Han Meilin’s daily works and suggested that he directly apply for the university. In Mr. Pang’s expectant eyes, Han Meilin was heated and took on this seemingly impossible task. Han Meilin, who had only been in junior high school for three months, finished the senior high school course in 21 days with a strong momentum. Even his eyes were temporarily blind because of overuse. He finally got the eighth place in the Central Academy of Fine Arts. Under the guidance of Bole, this wild-growing swift horse finally embarked on the professional road of art. In college, although Han Meilin majored in design, his paintings were recognized by many people.

Mr. Han Meilin is the first class teacher in the Central Academy of Arts and Crafts (third from the left in the front row).

　　In 1960, after graduating from Han Meilin University, he wanted to respond to the college’s call to go to Yunnan ethnic minority areas when filling out his assignment, but he was left as a teaching assistant in the Decoration Department of the Academy of Fine Arts because of his excellent performance. After teaching, Han Meilin created many excellent works and became a rising star in Ran Ran at that time.

　　In 1963, Han Meilin was transferred to Anhui to organize the Academy of Fine Arts, and was involved in the catastrophe of the times. He was unjustly imprisoned, and his body and mind were greatly devastated. But even in prison, he tried his best to draw. Without a pen and paper, he painted rice soup on his pants. When the rice soup dried, his white pants became "drawing paper", and he painted on it with branches, which became his light in the dark.

　　In 1972, Han Meilin was released from prison and was assigned to work in Huainan Ceramic Factory. The factory assigned him a crude dormitory of 6 square meters. Because there was a buttonwood tree outside the house, Han Meilin felt the vitality of the trees and named his hut Tongzhai. In the next six years, he lived in Tongzhai to create.

After he was released from prison, Mr. Han Meilin weighed only 36 kilograms.

　　After he was released from prison, although his living conditions improved, he still couldn’t afford the high cost of ink painting. In order to make ink painting paper show the ink smudge effect similar to expensive rice paper, Han Meilin combined traditional ink painting with modern watercolor painting and created a new technique of brush painting — — Brush a layer of water on the hard paper first, and when the paper is half dry, quickly draw a pen to make the ink pigment "smudge" along the water potential. This kind of creation is not achieved overnight. Too much water brushing will make the ink flow away with the water, and it is impossible to maintain the shape. Too little water brush will make the drawing paper dry too fast, which will affect the blooming effect. After thousands of adjustment attempts, Han Meilin finally found the balance point between water and paper, and even created a new ink and wash color matching method.

Mr. Han Meilin’s painting "Friends in Need"

　　"Love" is the eternal theme of Han Meilin’s art. He said: "Artists should love the world, our society, our children, animals, plants and everything with love." Although he suffered a lot, Han Meilin never showed his suffering in his works of art, from Erhei, a close friend of poodle in times of trouble, to a monkey, a fox and a squirrel … … The animal shapes in Han Meilin’s brush painting are smart, and the fuzzy effect of ink and wash combined with blooming adds a cuteness.

　　In 1978, Han Meilin was finally rehabilitated, transferred to Anhui Artists Association to engage in professional art creation, and later served as vice president of Anhui Painting Academy. The spring breeze of reform and opening-up blew away the gloom that had shrouded Han Meilin for many years, and his artistic life ushered in spring.

　　In 1979, Han Meilin held his first solo art exhibition in China Art Museum, and published the first collection of animal paintings "Still on Earth" in the following year. In the same year, Han Meilin was invited to be the first China painter to hold a solo exhibition in the United States after the reform and opening up, starting from new york, he toured 21 cities including Boston, and became famous at home and abroad.

　　In college, both the teachings of Chai Fei, Pang Xunqin and Zheng Ke and the friendship with Shen Congwen, who works in the Palace Museum, made Han Meilin deeply realize the profoundness of China arts and crafts. At that time, he was determined to follow the will of gentlemen, base himself on tradition and folk, and draw inspiration from land and history.

In 2003, the "Han Meilin Art Caravan" was held in Kaili, Guizhou.

　　Han Meilin was inspired by an Indian film "Caravan", in which a group of actors sat in a caravan, and his heart yearned for the action of collecting wind wherever they went. Since 1977, Han Meilin led his own art caravan members to "drive" on the land of China, with the purpose of "helping the poor through culture and collecting wind through art", and went to the fields to learn various folk art techniques, and at the same time helped local difficult manufacturers to revive with his own creations. His interests seem to have no boundaries, from exquisite Henan Jun porcelain and Yixing purple sand to simple straw weaving and wall hanging. "Weaving, dyeing, engraving, carving, painting, writing, cloth, wood, stone, grass and metal, all contact, learning and teaching", he has gained endless artistic inspiration from the people, and his own creative path is also.

In September 2018, "Han Meilin Art Caravan" was in Nantong.

　　Han Meilin always believes that image is the key to artistic creation. With image in mind, all kinds of materials can be used by him. He swims freely among ink, ceramics and bronze. When the times endow him with a new mission, he can devote himself to new creation at any time, so can painting and design.

　　In 1980, China Post began to issue the first series of stamps on the zodiac, and the fourth set of special stamps on the zodiac in the year of pig in Guihai, which was issued in 1983, was designed by Han Meilin. The green leaves of hearts painted on pigs are very eye-catching, which not only has the traditional paper-cut and shadow play style, but also means a happy life with hearts, full of folk joy and festive atmosphere. This simple and exaggerated style of folk art has attracted worldwide attention.

In 1983, Mr. Han Meilin designed the special zodiac stamp for the Year of the Pig.

　　Since then, Han Meilin has integrated his understanding of traditional Chinese zodiac culture into vivid animal images, not only taking charge of the design of special stamps and commemorative medals of Chinese zodiac for many times, but also gradually formed the Han Meilin zodiac art with both national charm and modern aesthetics, leading China traditional culture to go abroad again.

　　The Zodiac in Han Meilin’s Works

　　In 1989, Han Meilin Studio of China Artists Association was formally established, which is the first and only studio named after artists by China Artists Association. As a pilot project of market economy reform in the art field, Han Meilin led his team to create giant sculptures in 58 cities, such as Long Whistling in the Wind, Dashun Farming, Five Clouds and Nine Rus, Qian Jianglong, Qianwang Shooting the Tide, Huafeng Yingxiang, Hundreds of Birds Facing the Phoenix and Danfeng Chaoyang, etc., with more than 1,500 studio members at most. Han Meilin marks the rise of modern cities after China’s reform and opening up with a unique way of artists’ sculpture works.

Shenzhen Shekou Sculpture "The Golden Bull"

　　In 1996, the Atlanta Olympic Games was held in the United States, which coincided with the centenary of the modern Olympic Games. Han Meilin was invited to participate in the design competition of Olympic symbolic sculptures. It took him less than a month to complete the artistic conception and integrate the two Chinese elements, Tenglong and Huabiao, into the urban sculpture. Finally, the Five Dragon Bell Tower he designed stood out from the design schemes of 17 countries and was successfully selected.

The sculpture "Five Dragon Bell Tower" designed by Mr. Han Meilin for the 1996 Atlanta Olympic Games.

　　Han Meilin’s fate with the Olympic Games naturally continued in the process of China’s bid for hosting the Olympic Games. He successively presided over the design of the emblem, Olympic logo and mascot for the 2008 Beijing Olympic Games, making indelible contributions to the smooth hosting of the 2008 Beijing Olympic Games.

　　In 2000, after continuous creation and revision, we finally had the "Chinese knot" with simple and smooth lines and rich meanings that we see today.

Mr. Han Meilin designed the logo of Beijing Olympic bid.

　　The success of the Olympic bid is only the beginning, and greater challenges will follow. In 2005, the revision team composed of top experts such as Han Meilin began to revise the design scheme of mascots collected from all over the world, but the individual images such as rattle, panda and loong that entered the "final circle" could not perfectly show the theme of the 5,000-year Chinese civilization and the modern Beijing Olympic Games. When the design came to a deadlock, Han Meilin boldly proposed to design the mascot with a combined image instead of a single image. The new creative thinking found the key to the design of the mascot, and the embryonic form of "Fuwa" was born. After more than two months, Han Meilin closed the studio to further revise and improve the design scheme of "Fuwa", and was once taken to the hospital for a heart attack caused by sleepless nights.

Mr. Han Meilin and Fuwa "Huanhuan"

　　In 2018, the International Olympic Committee awarded Han Meilin the "Coubertin Medal" in recognition of his outstanding contribution to promoting the Olympic spirit. It can be said that he is still active in the front line of artistic creation in his octogenarian years, which is a true portrayal of the Olympic spirit.

　　Since ancient times, China’s calligraphy and painting have paid attention to "the same origin of calligraphy and painting", while Han Meilin became famous for his paintings, but he has long been attached to calligraphy. When I was a child, my family was poor, and I found ancient books such as Four-body Thousand-character Writing, Six-book Classification, Shuowen Gushua, etc. When I didn’t understand their meaning, I was able to regard them as picture books and appreciate the beauty of words and images. In the travel activities, Han Meilin picked up the lost ancient Chinese characters from the ancient rock paintings of Helan Mountain, and from the fragments of ceramics, bronzes, tortoise shells and stone carvings scattered all over the country. He called these ancient Chinese characters, whose pronunciation and interpretation can’t be tested, "deaf-mute beauty", and recorded them almost instinctively in his own conception book. After decades of accumulation, they have reached tens of thousands. Once in Hong Kong, Mr. Qi Gong came across the ancient Chinese characters written by Han Meilin in his notebook, and suggested that he create them artistically, as if to wake up the dreamer in a word, and Han Meilin was determined to create a "heavenly book".

Mr Han Meilin is writing a gobbledygook.

　　In 2007, Han Meilin spent 34 years collecting and writing the ancient Chinese character catalogue "Tianshu", which finally came out. He did not research the origin and interpretation of the characters, but pursued the visual beauty of the characters themselves, and performed it with modern aesthetics on the premise of retaining the structure and font of the characters. Huang Miaozi, a master of calligraphy and painting, wrote a poem for it, "Cangjie makes words and ghosts cry at night, and Merrill Lynch’s Tianshu is a god’s costume". "Tianshu" is also a book and a painting. After the first book was published, Han Meilin continued to collect, sort out and re-create, giving more modern life to ancient Chinese characters. He said that if his body permits, he would like to write the translated words, which is a gift that Han Meilin really wants to leave to the nation.

Gobbledygook size: 370*120cm Year: 2015

　　Like most artists, Han Meilin has made great efforts in his creation, but he doesn’t care much about business affairs. In 2001, Han Meilin was admitted to the hospital for bypass surgery due to heart problems. When his life was dying, there were thousands of works left in the studio and he didn’t know what to do with them. After his recovery, Han Meilin, who didn’t want to get close to business, decided to donate his works to the country for future generations to study. Under the direction of his wife, Zhou Jianping, Han Meilin Art Museum was built in Beijing and Hangzhou at both ends of the Grand Canal. Subsequently, Yinchuan Pavilion was completed and opened in 2015. Han Meilin became the first China contemporary artist with three art galleries (Beijing, Hangzhou and Yinchuan). Its scale, category and quantity are vast, and it is known as "Dunhuang for one person". Han Meilin has a mantra: "I am making progress every day!" The growth of age can’t stop him from pursuing art. Under the impetus of continuous creation, Han Meilin Zisha Art Museum was established in Yixing, the birthplace of Zisha Pot, in 2019. At present, the expansion projects of Beijing, Hangzhou and Yinchuan have also been carried out in an orderly manner.

Han Meilin Art Museum in Hangzhou, Beijing and Yinchuan

　　Over the years, Han Meilin has supported charity by donating money and works. In 2013, the Han Meilin Art Foundation was formally established, which enabled it to carry out art-related public welfare undertakings more systematically, regularly and continuously, promote cultural education and cultural inheritance by setting up scholarships, and donated funds to build Merrill Hope Primary School and Merrill Lynch classrooms in many places to promote the popularization of basic education and aesthetic education.

Donation ceremony of "Fuwa Nini Hope Primary School"

　　In 2015, Han Meilin was awarded the title of "Peace Artist" by UNESCO, becoming the first person in China art circle to win this honor. Since then, Han Meilin has more actively participated in the cause of promoting cultural exchanges and cultural inheritance in various countries and regions, and in 2016, launched the "Merrill Lynch’s World Han Meilin Global Tour Exhibition", with the purpose of "paying tribute to the Renaissance, returning to the roots of the nation, and performing cultural duties", and carrying forward the "peaceful" and "pluralistic" cultural world outlook with art, and promoting the great ideal of "truth, goodness and beauty" in human society.

Irina bokova, then Director-General of UNESCO, awarded Mr. Han Meilin the certificate of "peace artist".

　　Today, Han Meilin, who is 87 years old, still insists on writing and drawing every day, and maintains strong artistic creativity. Together with the art foundation he founded, he continues to promote the inheritance of national culture and international cultural exchanges. He calls himself a "time poor", so he should make up for the lost time in turbulent times with more diligent creation.

　　Han Meilin’s life is so rich that it is difficult for us to define him in one word. He has made outstanding contributions in painting, calligraphy, sculpture, ceramics and other fields. Even his life itself has been carved into a masterpiece of art in the pursuit of goodness and beauty for decades. Such a master is a wonderful blessing from God to the world and to China.

　　CCTV News:Issued by Jiangsu Meteorological Observatory at 08: 46 on December 18th, 2023.Blizzard blue warningIt is estimated that there will be more than 12 hours and 4 millimeters of snowfall in most areas of central and southern Nanjing, Zhenjiang, Changzhou, southern Taizhou and southwestern Wuxi from day to night today. The Provincial Emergency Department (Provincial Disaster Reduction Office) and the Provincial Meteorological Bureau reminded to take precautions.

　　Defense guide:

　　1. The government and relevant departments shall, in accordance with their duties, make preparations for snow disaster prevention and freezing injury prevention;

　　2 transportation, railway, electric power, communications and other departments should carry out road, railway and line inspection and maintenance, and do a good job in road cleaning and snow melting;

　　3. Pedestrians should pay attention to cold prevention and anti-skid, drivers should drive carefully, and vehicles should take anti-skid measures;

　　4. Farming and pastoral areas and breeding industries should reserve feed and prepare for snow disaster prevention and freezing injury prevention;

　　5. Reinforce temporary structures that are easily crushed by snow, such as scaffolding.

　　In addition, Jiangsu Meteorological Observatory issued it at 08: 19 on December 18, 2023.Yellow warning of road icingIt is estimated that there will be road icing in Nanjing, Xuzhou, Lianyungang, Suqian, Huai ‘an, Yancheng, Yangzhou, Taizhou, Zhenjiang, Changzhou and Wuxi that will have an impact on traffic today and tomorrow. The Provincial Emergency Department (Provincial Disaster Reduction Office) and the Provincial Meteorological Bureau reminded to take precautions.

　　Defense guide:

　　1. Traffic, public security and other departments should prepare for road icing according to their duties;

　　2. Drivers should pay attention to road conditions and drive safely;

　　3. Pedestrians should ride bicycles as little as possible when going out, and pay attention to anti-skid.

Author | Li Beichen

Source | Whale Fall Business Review

As we all know, today’s Chinese music scene is called "Shaking".

At the end of last year, Tencent Music made the top ten hot songs of the year, namely: Cloud and the Sea, Bai Yueguang and Zhu Shazhi, Gossip of the Prodigal Son, Dream that Can’t Wake Up, Treading on the Mountains and Rivers, Qian Qian Never Will Fall, Shepherd of Coco Tuohai, Emptying, and Obsession.

Almost all of them are Tik Tok Divine Comedy.

Yes, the most popular part of Chinese music has become the accompaniment of Tik Tok.

In the face of traffic, QQ Music and Netease Cloud Music also chose to bow their heads, with a special list of popular songs in Tik Tok, and QQ Music regarded "Tik Tok Hot Search" as a recommended option for searching songs.

Whether you like it or not, the subversion and controversy brought by Tik Tok to China’s music industry have become increasingly apparent. Those Tik Tok Divine Comedy haunts your mind, which has made the music market in China undergo an unpredictable evolution.

Obviously, Byte himself realized this, and then suddenly realized: "Why should I give up my own traffic?"

So they left the stage and entered the music market in person, which may completely change the appearance of the music market-and even the whole "music".

Traffic coordination in ByteDance

From the moment of its birth, Tik Tok has a close relationship with music-Tik Tok has a "sound" in his name, and the icon is also a note.

Looking back, Tik Tok’s predecessor, A.me, positioned itself as "short music video", which was quite similar to musical.ly, which was popular among American teenagers at that time, and created short videos by guiding users to lip-synch with music or dance. By the end of 2017, musical.ly had more than 200 million registered users.

Also in 2017, musical.ly was acquired by ByteDance, and then merged into the overseas version of TikTok in TikTok, which brought many active users and creators to TikTok and laid a good foundation for its rapid expansion in the global market.

ByteDance’s "formal" entry into the music market began two years ago.

In March, 2020, Byte officially launched the music playing software Resso in India and Indonesia. You can understand it as "Tik Tok in Music". Once the App is opened, it will be personalized song recommendation. If you don’t like this song, you can swipe the screen up and down like a Tik Tok and quickly cut to the next one.

Resso has been online for half a year, and the download volume has exceeded 15 million times. With this experience, in 2021, a music division was established within Byte, and a key task was to open up the music community of Resso and TikTok.

However, due to various reasons, Resoo has not expanded its territory to more countries and regions. At present, only a few countries such as India, Indonesia and Brazil are open.

In terms of music, perhaps the next force point of Byte is the domestic market.

In the spring of 2022, ByteDance launched an online music app-soda music in China.

The interface of soda music is very similar to Resso, which also uses sliding up and down to cut songs. Compared with the familiar left and right key switching, sliding up and down can greatly improve the speed of cutting songs. Under this interactive logic, people are not so much listening to songs as "brushing songs".

More importantly, according to media reports, most of the data of soda music and Tik Tok are synchronized. Soda music can help people to collect the divine comedy heard in Tik Tok synchronously, and find more similar songs in ByteDance’s proud algorithm recommendation.

Byte’s intention to engage in music is obvious, that is, to cooperate with the flow of Tik Tok and soda music.—— It is foreseeable that the soda concert will be more deeply bound with Tik Tok to form a closed loop of flow: Tik Tok can hatch the Tik Tok Divine Comedy and guide it to soda music; Those minority songs in soda music can also be hatched into "soda divine comedy" with the help of recommendation algorithm, which can be used to feed back short video with vibrato and become Tik Tok divine comedy, thus further consolidating Tik Tok’s position in the field of short video.

It does look wonderful.

In the future, music will eventually become shorter.

As for the penetration of bytes into the music field, what it means to the music market in China is a matter of opinion.

Please note that this article has no intention to talk about the vulgarization tendency of Chinese music. After all, there is no need to argue about the reality. The whole Chinese music presents a dangerous prosperity that will collapse once the coarse gravel foundation is removed. Huang Shujun has a song called "Change 1995", and there is a lyric that won my heart: "Only pop, no music, I think it is a good thing that you are out of sight."

So today, we are out of sight, avoiding "music quality" and talking about "music length".

Have you ever thought about it,When music can be "brushed", people will inevitably leave less and less time for a song, and they will become more and more stingy, so that they will never give you "time for a song" again.

Yes, now is not the era of "slow in the past". In the past, everyone was sincere: a song is a song; Movies, one is another. This is not the case now. People’s interest cycle is getting shorter and shorter, and the content carrier is also getting shorter and shorter, so that they can be embedded in people’s increasingly fragmented nothingness life at any time.

Therefore, just as people have become more and more impatient to watch the whole movie and are used to watching the short video of "watching a movie in X minutes", people have become more and more impatient to listen to the whole song and are used to going straight to the climax and only listening to the chorus (especially for new songs).

I even think,One day in the future, the online music platform will be completely "chorus", that is, every song that people brush will only have a climax.

If this is the case, then this new technology carrier will change the music-the time of a song is bound to become shorter, and the "memory points" such as melody and rhythm are bound to become more accurate-as much as the music was changed when vinyl was born.

You know, nowadays, a song usually lasts only a few minutes, thanks to vinyl. At first, there was no time limit for church music and court music (Beethoven’s Ninth Symphony lasted about 70 minutes), but as music can be stored, copied and distributed by new technology, a piece of music is also "framed" in the poor capacity of 4 minutes when vinyl was born. Musicians can choose not to compromise on technology, but as long as you want to seize the dividend of new technology, you must make the work shorter and make the melody and rhythm more accurate to meet the increasingly impatient attention of the audience.

Well, whether you like it or not, this process is repeating itself. The emergence of new technical media such as bytes makes human attention shorter than before, which also makes the time of a song shorter than before.

Maybe a hundred years later, the new generation of young people will look back at Jay Chou in the 21st century, just as we look back at Beethoven in the 18th century-"It’s just a song, why did you write it so long?"

Author: Li Beichen (WeChat: Whale Fall Business Review)

In today’s digital age, the bank’s security verification methods are constantly innovating. As a relatively novel and efficient verification method, gait password verification service brings more convenience and security for users. The following is a detailed introduction to how to handle the gait password verification business in the bank.

First, you need to go to the bank’s business outlets. Before you go, it is recommended that you prepare relevant identification documents, such as ID card and passport, in advance to ensure that the business process can go smoothly.

When you arrive at the bank, tell the lobby manager or counter staff that you want to do gait password verification. The staff will provide you with the corresponding application form, and you need to fill in your personal information carefully, including your name, ID number and contact information.

After completing the application form, give it to the staff. The bank will verify and verify your identity. This process may require you to provide some additional proof materials or answer some security questions to ensure that your identity is true and valid.

After passing the authentication, the bank will arrange professional technicians to collect gait data for you. This usually requires you to walk a certain distance and way on a specific device, so that the system can accurately record your gait characteristics.

After the gait data is collected, the bank’s system will analyze and process the collected data, and associate and bind it with your account.

In the whole process, you may need to wait patiently for a period of time, depending on the bank’s business processing speed and the complexity of the system.

It should be noted that different banks may have slightly different procedures for gait password verification business. The following is a list of the handling characteristics of several common banks:

In addition, after completing the gait password verification business, you need to take good care of your personal information and password to avoid revealing it to others. At the same time, pay attention to the relevant notices and tips of the bank regularly to understand the updates and changes of the business.

In a word, it may take some time and steps to handle the gait password verification business of the bank, but it can provide a higher level of protection for your account security and make you feel more at ease while enjoying the banking services.

[Disclaimer] This article only represents the author’s own views and has nothing to do with Hexun. Hexun.com is neutral about the statements and opinions in this article, and does not provide any express or implied guarantee for the accuracy, reliability or completeness of the contents. Readers are requested for reference only, and please take full responsibility. Email: news_center@staff.hexun.com.

Group photo of guests

People’s Daily Online, Beijing, March 19 (Wang Xiaohua) This year’s government work report puts forward that "people-centered development ideas should be adhered to, and efforts should be made to safeguard and improve people’s livelihood, and the people’s sense of gain has been continuously enhanced." Since the first three-year "Action Plan for Further Improving Medical Services" was officially launched in 2015, hospitals at all levels have made positive achievements in innovating service measures and improving people’s medical experience in view of the "bottleneck" problem of medical treatment. With the launch of the new round of improving medical service plan, how to make "seeing a doctor more comfortable, providing more considerate services and increasing people’s sense of obtaining medical treatment"?

During the two sessions of the National People’s Congress in 2018, People’s Daily Online and People’s Health jointly organized a series of roundtable forums on "Healthy Chinese". In the special session of "Further Improving Medical Services" held on March 15th, five guests from government agencies and medical institutions gathered at People’s Daily Online to discuss the beneficial measures of "Further Improving Medical Services".

Innovating medical service mode and improving patients’ accessibility to medical treatment

Jiao Yahui, deputy director of the Medical Administration and Hospital Authority of the National Health and Family Planning Commission, said that after the expiration of the first three-year "Medical Service Improvement Plan", patients’ access and satisfaction were improved through the extensive application of information technology, improvement of service quality, acceleration of sinking of resources and continuous improvement of medical services.

Jiao Yahui introduced that since China launched the first three-year "Action Plan for Further Improving Medical Services" in 2015, the service process has been optimized by means of Internet informationization, which has alleviated the long-standing problem of "three long and one short" (long waiting time for medical treatment, long payment time, long time for taking medicine and short time for seeing a doctor). Through the innovative service model, the number of patients going to and from the hospital, repeated queuing in the hospital, the whole waiting time for outpatient service and the average length of stay were effectively reduced.

According to the data of 5.87 million valid questionnaires of real-time online satisfaction survey, the overall satisfaction of outpatients and inpatients in tertiary hospitals in China reached 90.7 points and 93.9 points; The analysis of 28.83 million pieces of information related to medical services on the Internet shows that netizens’ overall feelings about medical services are positive, which fully reflects the positive results achieved in improving medical services in the past three years.

Building emergency specialist alliance and opening up the "green channel" for emergency patients

Li Weimin, deputy to the National People’s Congress and president of west china hospital, said that this year, Huaxi Hospital will focus on optimizing the medical treatment mode and improving the satisfaction of emergency patients. At the same time, through the construction of emergency specialist alliance, the information triage before emergency admission can be realized, and the rescue and treatment resources can be dispatched in time, so as to truly open a green channel for emergency patients to check and be admitted to hospital.

Li Weimin introduced that since the establishment of the telemedicine network in West China Hospital in 2001, more than 640 hospitals in 20 provinces and cities across the country have joined the telemedicine network, providing telemedicine education and multidisciplinary joint consultation for difficult cases in remote areas and ethnic minority areas, which not only enables grassroots patients to get timely diagnosis and quality treatment programs, but also improves the local medical service level.

Take effective measures to promote the appointment and medical association system

Feng Guosheng, chairman of Beijing Chaoyang Hospital affiliated to Capital Medical University, introduced the effective measures taken by Beijing Chaoyang Hospital in improving medical services in recent years. He pointed out that in terms of appointment diagnosis and treatment, since 2012, Chaoyang Hospital has adopted various forms to carry out appointment registration services to facilitate patients to see a doctor. In the process of diagnosis and treatment, the appointment time, including the examination time, is accurate to 15 minutes, which greatly reduces the waiting time of patients in the hospital and obviously improves the medical environment.

In terms of vigorously developing the construction of medical associations, in 2012, Chaoyang Hospital established a medical association with Chaoyang Hospital as the core and secondary hospitals and community medical centers as participants under the guidance of the government. Through the standardized operation within the medical association, more patients with common diseases and chronic diseases can enjoy the high-quality medical resources of large hospitals at their doorsteps.

Feng Guosheng said that Chaoyang Hospital has also realized telemedicine through information technology, and further strengthened the innovation of outpatient services, such as setting up symptom clinics and special disease clinics to facilitate patients to seek medical treatment.

Extend the service to the grassroots level and let more children enjoy health.

Ni Xin, dean of Beijing Children’s Hospital affiliated to Capital Medical University, pointed out that Beijing Children’s Hospital has implemented a comprehensive appointment system for non-emergency patients since June 2015. Through a variety of ways, patients are guided and facilitated to make appointments and time-sharing visits, so that the waiting time of patients is shortened, the peak flow of outpatients is reduced, and the medical experience is significantly improved. These methods mainly include: dynamically adjusting staff and improving service space; Implement centralized appointment for large-scale examinations to reduce patients’ running back and forth; Increase voluntary service and improve the online and offline guidance system; Open professional outpatient service and expert team outpatient service to make the process of treating intractable diseases more convenient.

Ni Xin introduced that in order to facilitate children to seek medical treatment nearby, Beijing Children’s Hospital and Children’s Research Institute took the lead to promote the common development of pediatrics in 16 municipal general hospitals in Beijing. By hosting three children’s hospitals, the medical level of local hospitals has been further improved. Beijing Children’s Hospital and 23 provincial children’s hospitals across the country set up a cross-provincial specialist alliance to achieve the goal of "doctors move and patients don’t move". In the next step, we will use artificial intelligence to comprehensively improve the level of medical services, extend services to the grassroots, increase support for poor areas, and let more children enjoy health.

Carry out the comprehensive upgrade of information system for the construction of smart hospitals

Jiang Lihong, deputy to the National People’s Congress and president of the First People’s Hospital of Yunnan Province, said that in the past three years, the First People’s Hospital of Yunnan Province has actively implemented the improvement of medical services, mainly focusing on two themes, and has achieved certain results: First, the construction of smart hospitals. The hospital information system has been upgraded in an all-round way, and the people’s appointment registration rate has increased from about 30% to more than 91% after the new system goes online. The hospital implemented the one-card service, and invested in the construction of 126 self-service machines. Patients can register for ID cards or medical insurance cards.

The second is the construction of medical association and graded diagnosis and treatment. People in Yunnan Province, especially in mountainous areas, live in scattered areas, and fewer patients in Yunnan Province are transferred to other provinces for medical treatment. The demand for medical associations and graded diagnosis and treatment is more urgent. The First People’s Hospital of Yunnan Province and 215 state (city) and county hospitals in the province formed a medical association, and 3-5 specialists were selected from 33 state-level hospitals to form a specialist alliance. At the same time, 6 provincial-level expert grass-roots workstations and 66 secondary hospitals and community expert teams were set up to build a "joint laboratory for precision medicine and eugenics" with the hospitals in the medical association, forming a multi-level assistance mechanism such as hospitals, specialist alliances and expert teams.

?　　Foreword　　

In 1993, Belgian scientists discovered a new antibody-nano-antibody (VHHs) in camel serum, which is different from the traditional antibody structure and only consists of heavy chain variable regions. Compared with traditional antibodies, nano-antibodies have the advantages of stable physical and chemical properties, low immunogenicity, strong tissue permeability, and can recognize epitopes that traditional antibodies cannot recognize, which makes them a strong and beneficial supplement to traditional antibodies.

Nano-antibody is only composed of heavy chain variable region, with small molecular weight and simple structure, which enables it to realize stable expression in various expression systems. So far, VHHs has been expressed in many expression systems, from prokaryotic cells, yeast, fungi, insect cells, mammalian cell lines to plants. This paper mainly introduces the expression of nano-antibody in different expression systems, and the present situation and development trend in the field of this system.

Prokaryotic expression system　Prokaryotic expression system is the earliest mature protein expression system studied. Obtaining foreign proteins through prokaryotes can obtain gene expression products in a short time, and the cost required is relatively low. The expression system mainly includes Escherichia coli expression, Bacillus subtilis expression and Streptomyces expression. Among them, Escherichia coli system is the most widely used, and the prokaryotic system generally refers to the expression of Escherichia coli.

Escherichia coli expression system　Escherichia coli expression system is the most important expression platform of recombinant protein in laboratory environment, and the expression is controlled by lactose operon. The host of Escherichia coli system has the advantages of fast growth, simple culture, low price, clear genetic background and high protein expression. However, it can not modify the expression product after translation, and the expression product contains a lot of endotoxin and is easy to form inclusion bodies.

Common host bacteria of Escherichia coli expression system

Periplasmic space, as the only compartment with oxidation environment in Escherichia coli, is the most commonly used expression system of nano-antibodies containing specific disulfide bonds. In addition to aerobic environment, there are many partners and isomerases in the periplasmic space, which can promote the correct formation of disulfide bonds and help protein fold. Nano-antibody protein is first produced in the cytoplasmic space, and then secreted into the periplasmic space through Sec pathway, SPR pathway or Tat pathway. After signal peptide is removed by signal peptidase, the target protein can be obtained [1].

Up to now, many VHHs have been successfully expressed in periplasm, some of which can reach tens of milligrams per liter, but there are still a lot of VHHs with low yield. This is because many fusion proteins can not be effectively secreted in the periplasmic space, and cytoplasmic expression seems to be the only expression mode of such fusion proteins [8].

The cytoplasm is a reduced compartment, so that the proteins expressed through the cytoplasm can not be folded correctly, and most of them are inclusion body proteins. The proteins are protected from the degradation of intracellular enzymes and are easy to be separated in high purity and concentration. However, there are many kinds of proteins in cytoplasm, and it is difficult to purify them. At the same time, nonfunctional inclusion proteins need to be completely denatured and refolded to be recovered from these inclusions, but the recovery of VHHs is usually inefficient [1]. In order to solve the problem of cytoplasmic expression, Xue X and others designed a new dialysis-dilution device in 2016. Using this device, researchers refolded VHHs and achieved a recovery rate of 85%, while the conventional dialysis and dilution methods only reached 13%[9]. Bacterial cytoplasm can be an effective compartment to produce correctly folded nanoparticles when expressed by recombinant vectors with sulfhydryl oxidase and disulfide isomerase activities. Larger volume and wider cytoplasm of chaperone/folding enzyme can achieve high yield of nano-antibody [6]. At the same time, double mutants with defects in thioredoxin and glutathione pathways have been developed. Some of these strains have been sold commercially in recent years, such as Origami (Novagen), Rosetta-gami (Novagen) and SHuffle?T7 (New England Biolabs) [10]. Among them, Shufflet 7 overexpresses a critical periplasmic isomerase DsbC, which can effectively catalyze the isomerization of disulfide bonds. Some studies have found that,The activity of isomerase DsbC can increase the yield of functional recombinant protein in periplasmic research [11].　　

Kavousipour Soudabeh and other modified vectors added four different signal peptide sequences to guide the secretion and expression of nano-antibodies, and found that TrBC signal peptide had the best effect [5]. Jianli Yu et al. used repetitive amino acid sequence motifs (GAGAGS) found in silk fibroin (SFP) as a new fusion tag (SF-tag) to enhance the expression of nanosomes in E.coli.. The transcription level of labeled protein is 2.3-7.0 times that of unlabeled protein, and the yield is increased by 2.5-7.1 times [27]. Xi Xie and others tried to select antifreeze protein AXX, and obtained its reverse transcription protein XXA by synthesizing XXA gene, which was used to develop new soluble fusion tags. It was found that the solubility ratio of fusion protein expressed by XXA fusion tag reached 86%, which was much higher than that of other tags [12].

Other prokaryotic expression systems　Lactic acid bacteria are the most common intestinal probiotics, which are generally considered to be harmless to human body and are very suitable for the production host of therapeutic molecules. However, the existing expression data show that the yield of VHHS produced by lactic acid bacteria is low, about 1-3mg/L, which is much lower than that of Escherichia coli [13,14]. Lactobacillus rhamnosus DSM14870, as a normal flora in human vagina, can express HIV antibody in the form of soluble or cell wall anchor fixation, and is a suitable expression host for HIV antibody [2]. When Bacillus brevis choshinensis was used for 3L fed-batch fermentation, the yield was as high as 3g/L[15]. This system is easy to manipulate genes, has no endotoxin and shows weak protease activity, so it is a very noteworthy system.

Eukaryotic expression system　

Due to the defects of prokaryotic expression system, such as difficult purification of inclusion body protein and incomplete protein modification, people began to use eukaryotic expression system to study genes. At present, eukaryotic expression systems commonly used in genetic engineering research include yeast expression system, insect cell expression system and mammalian cell expression system.

Yeast expression system　Yeast system has clear genetic background, simple operation, easy genetic operation, perfect eukaryotic protein expression control system and advantages of both prokaryotic and eukaryotic expression systems. Yeast eukaryotic protein expression systems include methanol yeast expression system, Saccharomyces cerevisiae expression system, Schizosaccharomyces expression system and Kluyveromyces expression system [17].

Saccharomyces cerevisiae is the first yeast fermented by human beings, which has no specific virus and low cost. At present, it is the largest yeast expression system in shake flask culture, with the output exceeding 100mg/L[16]. Some amino acids in VHHs can participate in the recruitment of molecular chaperones in endoplasmic reticulum, thus narrowing the difference of molecular chaperones between Saccharomyces cerevisiae and mammalian cells, which is beneficial to the folding kinetics of nano-antibodies and improving the yield of nano-antibodies in Saccharomyces cerevisiae [17]. The protein expressed by Saccharomyces cerevisiae is prone to hyperglycosylation, and a large number of endogenous proteins are produced during fermentation, so the secretion efficiency of the target protein is low [1]. Considering the above problems, Saccharomyces cerevisiae is gradually replaced by methanol yeast represented by Pichia pastoris.

Pichia pastoris expression system is an efficient expression system of foreign proteins. This microorganism does not accumulate toxic ethanol, but only secretes a few endogenous proteins, and its glycosylation degree is the same as that of mammalian cells, so its immunogenicity is weak, so it is the most commonly used eukaryotic expression system. Pichia pastoris has a strictly regulated methanol inducible AOX1 promoter, which is suitable for high expression of foreign proteins [1]. But methanol is a highly toxic and dangerous chemical product. The GAP promoter without methanol induction is used instead of AXOI, and the carbon source does not need to be changed during the culture process, so the operation is simpler and the time for foreign proteins to reach the peak level can be shortened. The yield and affinity of nanoparticles produced by this system are similar to those produced by methanol-induced expression. It has been studied that the yield of nano-antibody expressed by this system in shake flask is 51.71mg/L[18] and 16mg/L[19].

Fungal expression system　

Some filamentous fungi, such as Trichoderma and Aspergillus, can secrete a large number of foreign proteins in the culture medium. However, the fungal system not only expresses protein of interest, but also produces many proteases, which affects the yield. Joosten et al. obtained only 1.5 mg/L VHHs in Aspergillus awamori medium. After adding 0.25% BSA, it reached 7 mg/L. It is reported that more than 80% of VHH is degraded or adhered to the cell wall compared with endogenous xylanase secreted efficiently in this system, and researchers believe that the low secretion efficiency of VHHs is the bottleneck of fungal expression [20]. In order to overcome this limitation and protect VHHs from degradation, other researchers fused VHH with the high amylase A signal sequence (sTAA) of Rhizopus oryzae lipase (N28) and the N-terminal 28 amino acid fragment (N28), so that the highest yield of VHHs expressed in Aspergillus oryzae reached 73mg/L, which was 300-800 mg/L lower than that of Escherichia coli [21]. The final yield of GlaB-VHH fusion protein in Aspergillus oryzae can reach 610mg/L, which provides the possibility for high expression of nano-antibody, but its stability needs to be verified [22]. In addition, VHH[23] was expressed by maize head smut in unconventional secretion pathway.

Insect cell expression system　

Insect cells are a widely used eukaryotic expression system, and recombinant baculovirus vectors (such as AcMNPV) can specifically transfect insect cells. Its survival in nature is short, and the strong promoter is inactivated in mammals and cannot infect vertebrates, so the recombinant baculovirus is safe for human beings. Proteins with complex structures under the control of strong promoters may not be able to form correct folding and post-translation modification, which may lead to the aggregation of target proteins and reduce antibody production, so the expression yield of VHHs in this system is much higher than that of other types of antibodies [17].

Gómez-Sebastián and others used the improved baculovirus expression system (IBES? technology) to express VHHs for the first time. The chigger larvae were inoculated with different recombinant baculovirus inoculation methods. The yield of VHH extracted from larvae is 257 mg/L, and the recovery rate after purification is 50%[7]. When expressing anti-endothelial cell selection protein, Drosophila cell SC-2 secreted 12-14mg/L, but the target protein was not detected when expressed in Escherichia coli at the same time, which may be related to the processing and modification ability of insect cells [26].

Mammalian cell expression system　Mammalian cells are the best expression system for therapeutic antibodies, because the produced antibodies have the weakest immunogenicity. At present, the main cell lines include CHO, NS0, Sp2/0, HEK293 and per C6 [17]. Among them, CHO cells grow rapidly and adapt to serum-free suspension culture, which is the most popular host. They can express VHHS up to 100mg/L in shake flask [24]. HEK293 cells are more commonly used in the laboratory because of transient transfection and semi-stable expression, because they require less time and labor. However, monoclonal antibodies approved for the treatment of human diseases are only produced by CHO, NS0 and SP2/0. So far, HEK293 cells have not been used to produce VHHs, and there are few reports about producing antibody fragments by this method [17]. In most literatures, CHO is used to produce antibody fragments. Up to now, 50% of the therapeutic proteins produced in industry are still produced by CHO [1]. The production costs associated with mammalian cell lines are much higher than those associated with any other laboratory research platform.

Common host cells of mammalian expression system

Plant expression system　Compared with other expression systems, plant production platform (stable and transient expression system) is cheap, safe, capable of folding and assembling complex proteins and post-translation modification, easy to expand, and unaffected by human pathogens and diseases. It is an ideal protein expression host and is usually used as an alternative method for mammalian expression systems. In addition, plant expression products can be concentrated in specific organs, such as leaves or seeds, and can be taken orally directly. Tobacco leaves are the most common hosts for expressing VHHs, while the proteins expressed in Arabidopsis and rice seeds have attracted much attention because of their direct oral input of VHHs[1]. The stable transformation methods commonly used in plant system expression have some problems, such as the recombinant gene escaping to nature or the time-consuming transformation. Therefore, some studies have proposed the transient expression system of plant virus expression vector as an alternative method, and the nano-body content with correct conformation reaches 0.45% of the total soluble protein [25].

Present situation and development of nano-antibody expression　

Escherichia coli expression system is the most commonly used expression system of nano-antibody, which has two expression modes: periplasmic expression and cytoplasmic expression, each with its own advantages and disadvantages. Some oxidation engineering strains have been modified, but more experimental support is needed. In addition, various methods of modifying vectors, such as adding labels or signal peptides, have been put forward and have been verified by experiments. Compared with Escherichia coli, Pichia pastoris has excessive glycosylation, which may lead to immunogenicity and ultimately affect its clinical application. The expression systems of fungi, insects, plants and mammals are much more complicated than prokaryotic and eukaryotic expression systems, and are generally not easily adopted after considering the production time, cost and laboratory conditions.

Escherichia coli system is fast, convenient and cheap, and it is the first choice for VHH expression under most laboratory conditions. When some types of VHHs can’t be successfully produced in E.coli, other systems will be used instead.

List of nano-antibody expression

　　"My temperature is only 35.6℃, is it normal?" "My child’s temperature is 37.2℃. Is it a fever?" "How does my temperature rise and fall in a day?" "I saw on the Internet that higher body temperature means stronger immunity. Is that right?" … … Since the nationwide monitoring of body temperature and the comprehensive investigation of COVID-19 in Wuhan on February 6th, people have paid unprecedented attention to body temperature.

　　Body temperature is one of the important indicators to measure human health. As we know, whether it is a serious illness or a minor illness, a chronic disease or an acute disease, the first thing a doctor does when entering a hospital is usually to measure the patient’s temperature. If we are not feeling well, we will also take our temperature. On February 9th, in response to the public’s many doubts about body temperature, this newspaper invited relevant medical experts to elaborate on body temperature.

　　How much is the body temperature normal?

　　Shu Yingchun, deputy chief physician of Wuhan Children’s Hospital: Normal body temperature is not a specific temperature point, but a temperature range. The body temperature in the deep part of the body is relatively constant, which is called deep body temperature; However, the surface temperature is affected by many factors, with great changes and differences, which is called surface temperature. The clinical body temperature refers to the average deep temperature. Generally, the body temperature of the mouth, rectum and armpit is represented, and the rectal body temperature is closest to the deep body temperature. The normal range is: oral sublingual temperature is 36.3℃-37.2℃, rectal temperature is 36.5℃-37.7℃, which is higher than oral temperature (0.2℃-0.5℃) and axillary temperature is 36.0℃-37.0℃.

　　The standard of normal body temperature is based on the value of most people, not the absolute value of individuals. Each individual’s basal body temperature is different, so the same temperature, for one person, may be normal body temperature and will not cause discomfort, while for another person, it may be fever. The basal body temperature is generally the oral temperature measured immediately after sleeping for 6-8 hours without any interference, such as standing up, moving, eating, etc. Night shift workers can measure it after sleeping for 6-8 hours.

　　How to measure body temperature?

　　Shu Yingchun, Deputy Chief Physician of Wuhan Children’s Hospital: The temperature is measured by mercury thermometer. When measuring the body temperature, the mercury column of the thermometer should be thrown below 35℃, then wiped and disinfected with a cotton swab dipped in alcohol, and then held under the armpit for 5 minutes. When reading the thermometer value, the eyes should be on the same plane as the highest mercury. Although the electronic thermometer is convenient and safe, it is prone to errors. It can be added or subtracted from the temperature measured by the mercury thermometer, thus reducing the errors.

　　Why does the body temperature fluctuate?

　　Shu Yingchun, deputy chief physician of Wuhan Children’s Hospital: The body temperature is not fixed, but it fluctuates with factors such as gender, age, day and night, exercise and mood changes, but this change is often within the normal range.

　　Gender factors: Generally speaking, women are slightly higher than men, and women are slightly higher in premenstrual and early pregnancy, and ovulation period is lower.

　　Age factor: Neonatal body temperature is easily influenced by external temperature, which can be slightly higher than that of adults. The elderly have low body temperature because of their low metabolic rate.

　　Time factor: Generally, the body temperature is the lowest at 2-5 in the morning, and the highest at 5-7 in the afternoon, with a range of about 0.5℃-1℃. If you work at night for a long time, your body temperature will increase at night and decrease during the day.

　　Emotion and exercise: Sympathetic nerve is excited when emotion is excited, and skeletal muscle contracts during exercise, which can raise body temperature slightly.

　　In addition, the change of outside temperature and eating can make the body temperature fluctuate.

　　Is low body temperature bad for immunity?

　　Recently, it is widely rumored on the Internet that the normal human body temperature of 37℃ has become a history, which has dropped by 0.4℃ in less than 200 years since the 19th century. For every 1℃ drop in body temperature, the immunity will drop by about 30%. When the body temperature rises by 1℃, the immunity will be improved by 5-6 times.

　　Shu Yingchun, deputy chief physician of Wuhan Children’s Hospital: We take 37.3℃ as the temperature of children’s fever in clinic. When we measure the temperature of children with non-fever diseases, it is almost lower than 37℃. However, there is no statistical data to support whether it has dropped by 0.4℃ in 200 years.

　　Professor Wang Xiaochuan, deputy director of the Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, and doctoral supervisor: Although there is no specific research on how much immunity will decrease or increase after the body temperature drops and rises, the higher the body temperature, the stronger the immunity will indeed appear. This is because the higher the body temperature, the more immune cells will be activated in the human body, so that the invading pathogenic microorganisms can be better annihilated and the health of the body can be maintained.

　　How to raise body temperature?

　　[Soak your feet every day]

　　Liao Haolei, Professor of Clinical Epidemiology, School of Health, Wuhan University: Strengthening exercise and nutrition can really improve the basal metabolic rate and basal body temperature. However, "Rome wasn’t built in a day", and exercise and nutrition need long-term persistence. Facing COVID-19, we need to raise our body temperature and enhance our immunity through physical therapy and behavioral therapy: it’s best to wear a hat in winter, soak our feet and take a hot bath every day, and drink more hot water. Now everyone stays at home and can soak their feet three times a day.

　　[gentle exercise]

　　Zhang Qingsong, an expert in sports medicine in the Fourth Hospital of Wuhan, said: If the measurement error is ruled out, there are indeed some people whose body temperature is low for a long time, which is physiological, not pathological. It has no effect on the health of the body. Exercise can temporarily raise body temperature, and the degree of body temperature increase is related to the intensity of exercise.

　　This kind of hypothermia person, after he recovers from exercise, his body temperature will still fall back to his usual level, which is normal and does not need special attention.　

　　According to scientific research, long-term exercise has a positive effect on improving immunity. Exercise can obviously improve cardiopulmonary function and chronic diseases. Long-term moderate exercise can improve the body’s immunity and reduce the risk of infectious diseases. However, during 3~72 hours of intensive exercise, people will be in the "empty window period" of immunity, and they are more vulnerable to pathogen infection than usual.

　　Therefore, at present, under the epidemic situation, it is not recommended to cram for high heart rate and high intensity exercise temporarily, which will reduce the resistance.

　　Therefore, if you don’t have fitness habits, don’t rush to iron or sweat on the treadmill. Young people do flat support and push-ups at home, and walk fast on the treadmill. Middle-aged and elderly people can play Tai Chi and do health exercises. It is a good choice for women to do aerobics and yoga for about 30 minutes. When exercising, the heart rate is between 120 and 150, which not only achieves the exercise effect, but also does not exceed the physical endurance of ordinary citizens.

　　(Reporter Tang Zhifeng Yan Yan Wang Chunyu Li Qing)

The number of diabetic patients in the world continues to grow. Relevant data show that there is one diabetic in every eight adults in China and one pre-diabetic in every two adults in China.

Diabetes is not terrible, but its complications, such as cardiovascular and cerebrovascular diseases, renal failure, diabetic foot and retinopathy … These chronic complications have gradually become the main cause of death for diabetics.

Dangerous chronic complications of diabetes mellitus

Diabetes is a group of lifelong metabolic diseases caused by multiple causes and characterized by chronic hyperglycemia. The key to lowering the blood sugar level in the body is insulin, which helps glucose from food to enter cells from the blood to generate energy. When insulin is not well produced or utilized, the blood glucose level will rise, and when it rises to a certain extent, diabetes will occur.

Elevated blood sugar is not the end point of diabetes. Long-term high blood sugar damages the body, causing pathological changes in various important organs of the human body. With the extension of the course of disease and poor blood sugar control, diabetic patients will gradually develop chronic complications. Complications will have serious consequences in the later stage, such as blindness, renal failure, myocardial infarction, heart failure, stroke and amputation, which will seriously affect the quality of life of patients.

Chronic complications of diabetes are generally divided into macrovascular complications, microvascular complications, neuropathy and diabetic foot.

I. Cardiovascular diseases

Atherosclerosis is one of the main causes of cardiovascular diseases, and insulin resistance and hyperglycemia are the main factors leading to cardiovascular complications in diabetic patients. Studies have shown that diabetic patients have an increased risk of heart failure and/or cardiac dysfunction, and long-term hyperglycemia can also lead to various cardiac dysfunction, including arrhythmia and sudden cardiac death.

1. Symptoms and manifestations

There may be no symptoms in the early stage, and with the progress of the disease, discomfort symptoms such as chest pain, chest tightness, palpitation, shortness of breath and arrhythmia may appear after work. Some patients may have no obvious pain even when myocardial infarction occurs because of the influence of hyperglycemia on cardiac autonomic nerves.

2. How to screen

For diabetic patients, ECG and echocardiography should be performed at the time of diagnosis, and at least once every six months.

Hyperglycemia increases the risk of stroke. A comprehensive analysis of 102 prospective studies found that compared with non-diabetic patients, the risk of ischemic stroke increased by 2.3 times and the risk of hemorrhagic stroke increased by 1.6 times. This correlation is not only related to the incidence of cerebrovascular disease, but also related to the prognosis and functional status of the disease.

Second, cerebrovascular diseases

1. Symptoms and manifestations

If diabetic patients have symptoms such as dizziness, black eyes or blurred vision, slurred speech, numbness and weakness of one limb, they should be on high alert for possible cerebrovascular diseases and seek medical advice in time.

2. How to screen

If diabetic patients have danger signs of stroke, they should immediately have brain CT or magnetic resonance (MRI) and other related examinations.

Third, kidney disease

Diabetic nephropathy is a common microvascular complication of diabetes, which affects about 25% of diabetic patients. It has become the main cause of chronic kidney disease and end-stage renal disease.

1. Symptoms and manifestations

There are usually no obvious symptoms in the early stage, and some patients may have increased urine foam, renal function damage, hypertension and edema. When the disease develops to the advanced stage, severe renal failure and uremia may occur, and dialysis treatment is needed.

2. How to screen

Generally speaking, patients with type 2 diabetes have a urine test every six months to one year to detect the content of microalbumin. If the index rises abnormally, it is recommended to seek medical examination.

Fourth, retinopathy

Diabetic retinopathy is one of the common complications of diabetes and one of the main causes of blindness.

1. Symptoms and manifestations

There may be no symptoms in the early stage, but with the progress of the disease, symptoms such as blurred vision, visual field defect, decreased vision at night, and floaters may appear. In the late stage, it may develop into serious situations such as retinal hemorrhage and retinal detachment.

2. How to screen

It is recommended that diabetic patients have an annual fundus examination, including optometry, intraocular pressure measurement and fundus examination. Fundus examination can observe the retina by dilating the pupil.

V. Neuropathy

Diabetic neuropathy refers to the damage of diabetes to the nervous system, including the involvement of peripheral nerves and autonomic nerves.

1. Symptoms and manifestations

Common symptoms include paresthesia (such as pain, tingling and numbness), impaired motor function, digestive system problems (such as delayed gastric emptying and constipation) and sexual dysfunction.

2. How to screen

Diabetic patients should have regular nervous system examination, including foot examination, electrophysiological examination and autonomic nervous function test.

6. Diabetic foot

Diabetic foot is one of the serious and costly chronic complications of diabetes, which can lead to amputation and death. In China, the incidence of new foot ulcers in diabetic patients over 50 years old is 8.1% within one year, and the incidence of new foot ulcers in cured diabetic patients is 31.6% within one year.

1. Symptoms and manifestations

In the early stage, numbness and abnormal temperature sensation of the foot may occur, and then redness and skin breakage may occur, which will gradually increase.

2. How to screen

All diabetic patients should have their feet examined regularly.

Check the foot skin for abnormal cyanosis and ulceration;

Check whether the pain, temperature and touch of extremities are normal;

Check whether the pulsation of dorsal foot artery and posterior tibial artery is weakened;

If you suspect vascular diseases, you can check the vascular ultrasound of lower limbs.

"Misunderstanding" of Diabetes

The complications of diabetes are closely related to the degree of blood sugar control. Only by paying attention to the changes of blood sugar can we prevent and control the acute and chronic complications of diabetes. In this regard, there are some misunderstandings that need special attention.

1. Is there no problem without symptoms?

Answer: Wrong!

Many patients often neglect the treatment and management of diabetes in the early stage of diabetes because the symptoms are not obvious, which leads to long-term substandard blood sugar and poor control, which further affects all systems of the whole body and increases the risk of complications.

Once you are diagnosed with diabetes, whether you have symptoms or not, you should insist on regular, scientific and reasonable treatment. Only in this way can we effectively control blood sugar and reduce complications.

Experts remind that the severity of diabetes can not be judged only by the severity of symptoms.

2. Can I stop hypoglycemic drugs without authorization?

Answer: Wrong!

Diabetes is a lifelong disease, and it can’t be cured at present. Just because the symptoms disappear and the blood sugar drops to normal after regular treatment does not mean that the diabetes has been cured, and the drug treatment can be stopped immediately.

The vast majority of patients still need to continue to receive medication after their condition is stable. If the drug is stopped at will, the blood sugar will fluctuate. At this time, the original dosage may not achieve the ideal hypoglycemic effect, and it may be necessary to increase the dosage or even use a variety of hypoglycemic drugs in combination, which will also cause certain damage to the body.

Experts remind: strictly following the doctor’s instructions for drug treatment is the key to control blood sugar and reduce complications.

3. If the blood sugar control is normal, can you relax your diet management?

Answer: Wrong!

In the treatment of diabetes, diet management is very important, which is called one of the "five carriages" of diabetes treatment. Others include exercise, medicine, blood sugar monitoring and self-management education. Failure to control diet is likely to lead to large fluctuations in blood sugar, which is not conducive to maintaining a stable metabolic state and weight.

Experts remind that diet management should run through the whole process of diabetes treatment, so don’t let your guard down just because the blood sugar results are normal, so as to avoid serious consequences due to the unpredictable risk factors such as inaccurate blood sugar monitoring results and drug taboos.

Do all diabetics have complications?

Not all diabetics will have complications.

At present, in clinic, there are many patients whose blood sugar, blood lipid, blood pressure and other indicators have reached the standard, and the course of disease is as long as 30-40 years. It can be seen that diabetic patients should pay attention to the control of blood sugar and cannot ignore the condition.

At the same time, we should follow the doctor’s instructions for drug treatment, and we should not stop taking drugs at will. Diet management is also very important in the treatment of diabetes, even if blood sugar control is normal, diet management can not be relaxed. In addition, not all diabetic patients will have complications, and following the standard treatment can reduce the risk of complications.

1. Control blood sugar, blood pressure and blood lipid.

Achieving the standard of blood sugar is the key to prevent complications in diabetic patients. The general ideal targets are: fasting blood glucose 4.4 ~ 7 mmol/L, postprandial blood glucose ≤10mmol/L, glycosylated hemoglobin (HbA1c)<7.0%, depending on the patient’s age and complications.

Even for patients with well-controlled blood sugar, blood sugar should be monitored 2 ~ 4 times a week. For patients with high blood sugar fluctuation or high blood sugar, blood sugar should be monitored 7 times a day, and treatment should be adjusted in time.

The control of blood pressure and blood lipid plays an important role in reducing the complications of diabetes and the risk of heart disease. Blood pressure should be monitored every time you visit a doctor, and blood lipid and electrocardiogram should be checked at least once a year.

Step 2 change your lifestyle

Reasonable diet, low fat and less oil, small amount of meals, regular quantitative meals. Quit smoking and limit alcohol, exercise properly, work and rest regularly, and control weight.

Step 3 check regularly

Diabetic patients should go to the hospital regularly for relevant examinations, which is not only beneficial to blood sugar control, but also can actively prevent complications and strive for early detection and early treatment. Screening mainly includes blood biochemical examination, glycosylated hemoglobin, urine routine, microalbuminuria, electrocardiogram, fundus examination, neuropathy screening, vascular B-ultrasound, etc., so as to achieve early detection and early treatment.

Read the original text

　　When it comes to cancer, our first impression is often a terminal illness, which makes people "talk about cancer." The data shared at the 10th annual meeting of the National Cancer Center shows that the 5-year survival rate of cancer in China has increased from 30.9% to 40.5% in the past decade. Although the incidence of cancer has increased, with the change of public concept and the progress of medical treatment, cancer has become a chronic disease in China. ①②

　　Figure from White Deer Video ②

　　In fact, it may take several years from early cancer to late cancer. And with the development of medical technology, after scientific treatment, the five-year survival rate of many cancers has been above 90%.

　　Cancer has become a chronic disease.

　　The "Core Information and Knowledge Points of Cancer Prevention and Control" issued by the CDC of the National Health and Wellness Commission pointed out: "Cancer is a kind of chronic disease that seriously endangers people’s health." ③

　　It may take several years for cancer from early stage to late stage.

　　The development of most cancers is not so fast, and the pathogenic process of cancer is also very long. It takes quite a long time from normal cells to cancer cells, from continuous division and proliferation into cell clusters to "visible" diagnosable cancer nodules, ranging from a few years, usually taking more than ten to twenty years, or decades. ④

　　It’s just that some symptoms are ignored by us as ordinary physical discomfort, so that once they are discovered, they are in the late stage. Naturally, they feel that the disease is progressing rapidly and it is difficult to treat and recover.

　　Figure from Shanghai CDC ⑤

　　2. Scientifically treat some cancers, and the five-year survival rate is over 90%

　　With the change of people’s concept and the progress of medical level, cancer has changed towards the development direction of chronic diseases in China. In 2021, according to the statistics of the National Cancer Center, the five-year survival rate of malignant tumors has increased from 30.9% ten years ago to 40.5% at present, an increase of nearly 10 percentage points. For some malignant tumors, such as esophageal cancer, the five-year survival rate has been higher than that of developed countries such as the United States. ⑥

　　Yao Zhendan, deputy chief physician of the Fourth Ward of Gastrointestinal Cancer Center of Peking University Cancer Hospital, said in a video interview with Bailu that the treatment effect of early cancer is excellent. According to statistics, the five-year survival rate of early gastric cancer and intestinal cancer is above 90%, the five-year survival rate of middle gastric cancer is about 50%, and the five-year survival rate of middle intestinal cancer is about 70%. Even for patients with advanced cancer, the survival rate becomes better after treatment, and the survival time with cancer is longer. ②

　　Image from White Deer Video

　　Therefore, early detection and treatment of cancer is very necessary.

　　15 small signs of pre-cancer to know!

　　What are the symptoms and signs of early cancer? This is a problem that many people are concerned about. Pan Zhanhe, deputy chief physician of the Department of Oncology, Zhongshan Hospital affiliated to Xiamen University, listed 15 possible symptoms and signs in the early stage of cancer in the "Oncologist" WeChat publication in 2018 for your reference. ⑦

　　1. Masses and nodules

　　Mass nodules are not necessarily cancer, we can make a preliminary judgment on it:

　　Look at the size. The smaller the nodule, the more likely it is to be benign, of course, it is not absolute, so we should pay attention to follow-up and review; Pay attention if the nodule is more than 1 cm. Note that nodules that continue to increase, especially those that increase rapidly, tend to be malignant and should be paid special attention to.

　　Look at the texture. Soft or cystic masses tend to be benign; Hard, fixed or solid masses tend to be malignant, but the swollen lymph nodes of lymphoma are tough to the touch.

　　Third, look at the boundary and activity. Benign tumors usually have clear boundaries and good activity; Most malignant tumors have unclear boundaries, often adhere to or fuse with surrounding tissues, and their activity is poor.

　　Health Times Mao Yuanyuan/photo

　　2. Persistent pain is not traumatic

　　If there is persistent pain in a certain part of the body that is not caused by trauma and has unknown reasons, you should go to the hospital to find out the reason.

　　3. Cough if you don’t cure for a long time

　　For chronic cough or blood in sputum, especially long-term smokers, we should be alert to the possibility of lung cancer.

　　4. Unexplained total fever

　　If the cause of fever is unknown and persists, you should be alert to the possibility of cancer and conduct relevant examinations as soon as possible.

　　5. Inexplicable emaciation and fatigue

　　If you don’t take the initiative to lose weight, you don’t deliberately go on a diet, but you lose weight for unknown reasons, or you are accompanied by anorexia, fatigue, fatigue, etc. To find out the reasons, emaciation and fatigue may also be one of the manifestations of cancer.

　　6. No trauma but bleeding

　　Non-traumatic abnormal bleeding, such as hematochezia or hematemesis, should pay attention to exclude the possibility of intestinal cancer and gastric cancer; Beware of lung cancer when coughing up blood and taking blood in sputum; Irregular vaginal bleeding or menstrual bleeding may be related to gynecological tumors such as endometrial cancer and ovarian cancer. Painless hematuria or dysuria, beware of urinary tumors; Non-traumatic epistaxis should be careful to rule out nasopharyngeal carcinoma.

　　7. Abnormal digestion persists.

　　If indigestion persists, or accompanied by acid reflux, heartburn, abdominal pain and discomfort, we should be alert to the possibility of gastric cancer or esophageal cancer.

　　8. Obstruction of swallowing food

　　If you have a feeling of bloating or burning behind the sternum, pain behind the sternum, or a feeling of foreign body in the esophagus, especially the feeling of swallowing food obstruction, you should be alert to the possibility of esophageal cancer and laryngeal cancer.

　　9. hoarseness persists and is difficult to recover

　　If hoarseness is difficult to recover and lasts for a long time, we should be alert to the possibility of laryngeal cancer, lung cancer and so on invading or oppressing the recurrent laryngeal nerve.

　　10. Changes in stool habits and characteristics

　　If the habit, frequency or character of stool changes (such as thin stool shape, pus in stool, blood and mucus, etc.), or constipation and diarrhea alternate, be alert to colorectal cancer and go to the hospital for examination as soon as possible.

　　11. White spots increase burning and itching

　　Oral leukoplakia, leukoplakia of female vulva or male penis glans rapidly expand with burning itching, and attention should be paid to eliminating canceration.

　　12. Mole enlargement and discoloration

　　If the mole suddenly increases, the edge becomes irregular or the color changes, or there is bleeding or burning pain, and the original hair on the mole falls off, it is suspected that melanoma may be possible.

　　13. Fracture is easy to occur.

　　Fractures that are easy to occur without obvious or slight external force may be pathological fractures, so we should be alert to bone malignant tumors. Teenagers should pay attention to leukemia if they have non-traumatic joint pain and swelling.

　　14. Ulcer wounds persist for a long time

　　If the skin wound or ulcer persists, be alert to the possibility of skin cancer. Oral ulcer is very common, but if it cannot heal for a long time, we should be alert to the possibility of oral cancer.

　　15. Abnormal changes in male breasts

　　Although male breast cancer is rare, if male breast grows abnormally or has other abnormal changes, you should be alert to the possibility of male breast cancer and go to a breast specialist as soon as possible.

　　Of course, these manifestations are not necessarily cancer, but remind you to pay attention to it and go to the hospital for further examination to make a clear diagnosis.

　　Early and timely detection,

　　Kill cancer in the cradle

　　For ordinary people, regular physical examination can keep abreast of their physical health; Especially in the age of high incidence of cancer, timely screening can minimize the risk. Recommendations for screening and prevention of common malignant tumors in residents (2023 edition)
It is suggested that ordinary people with general risks can arrange screening in this way: ⑧

　　Health times chart

　　For high-risk groups, especially those with a family history of cancer, screening and physical examination should be done in advance and regularly according to the doctor’s advice.

　　This article is synthesized from:

　　① On March 29th, 2023, Shanxi Daily held the 10th Annual Academic Conference of National Cancer Center.

　　② 2023-08-14 White Deer Video "# Cancer has become a chronic disease in China #"

　　③ Key Information and Knowledge Points of Cancer Prevention and Control by CDC of National Health and Wellness Commission.

　　④ 2020-09-29 WeChat WeChat official account "Oncologist" "Who is easy to get cancer? Doctors say that people with cancer belong to these five categories! 》

　　⑤ 2020-06-30 Shanghai CDC "Science of Cancer Prevention? Is cancer a chronic disease? 》

　　⑥ Written Record of the Regular Press Conference of the National Health and Wellness Committee on April 27th, 2021.

　　http://www.nhc.gov.cn/xcs/s3574/202104/df811bc1ee8b4c8db0f0561758172ca8.shtml

　　⑦ 2018-10-29 oncologist "The most comprehensive cancer science: cancer prevention, early diagnosis, screening and treatment. The whole article includes "

　　⑧ Recommendations for Screening and Prevention of Common Malignant Tumors among Residents (2023 Edition). Shanghai Anti-Cancer Association, Cancer Hospital Affiliated to Fudan University.

Original Su Yibai S Miss Lan and Miss Huang

A lady has never been a pleasant existence in life.

Eva Huang, as one of the real ladies, appeared in a huge dress, and one person occupied three seats, so that people could wait on her anytime and anywhere and do whatever they wanted. Everyone should make way for me, which made the audience dumbfounded.

▲ For example, I took Meng Jia’s resignation as a matter of course, and I didn’t show any sign of Meng Jia helping her with her dress (at least not at all in the program broadcast, not even simply saying "thank you" later, so I was too busy talking to Yuqi Zhang next to me).

▲ Because the huge princess dress was too tight, she volunteered to adjust the order of appearance with Lyric, and picked up Meng Jia’s coffee and drank it directly before playing. Still, there was no thank you. Seeing Meng Jia carefully holding the coffee cup, her brain made up an inner drama.

▲ Gina silently helped her change her shoes, but she still turned a blind eye and didn’t thank her all the time.

During the whole program, Eva Huang regarded herself as a princess and a wealthy housewife, and even felt that it was natural for other female stars to take care of her and listen to her. Her words and deeds naturally attracted the audience’s dissatisfaction.

But are all ladies like this? Arrogant, conceited, arrogant and self-centered?

Of course not.

In fact, there are also annoying ladies. Today, we will talk about a lady who is almost uniformly praised. Although some people will say that her wealth is not comparable to that of Eva Huang, she is rich and talented and can be liked, which is a skill in itself.

People who often watch Kangxi Comes must know her. Her name is Melody (stage name: Yin Yue).

▲ The real name Liu Gongxian was nicknamed "Liu Hard Gun" by Xiao S.

She has a more impressive identity, Tao Zhe’s ex-girlfriend and the heroine of Tao Zhe’s masterpiece Melody.

▲ This was admitted by Tao Zhe himself in an interview in 2003. In the song, the phrase "I didn’t know how to cherish until I lost it" expressed the sadness of separation, and he also personally mentioned in the MV the regret that the good old days were hard to reproduce after all.

▲ Although Melody clarified in Kangxi many years later that this song was called Sara Lee (a cake brand) during the demo period, it was not a single specially written for her to some extent, but in the end, it was named after her, which is another kind of infatuation.

▲ This kind of "clean-up" is regarded by Tao Zhe fans as "turning your face and denying people". After all, her early fame in the entertainment industry largely came from the addition of this song. Looking back at her visit to Kangxi in early 2005, she was not shy about it.

But after all, this affair has long been a thing of the past, and both sides have their own families, so it is the best choice to forget about the rivers and lakes.

The two had been dating for six years, almost from Melody’s 18 to 23, and she was the first open girlfriend since Tao Zhe debuted.

▲ She never responded positively to the reason why the two broke up. She only said that she did not commit evil. At first glance, such a pretentious move is very disobedient, but people who are used to watching her show say that this is her, drama queen.

Melody, born in the United States in 1979, is a standard ABC, so her ABC accent has also become a personal feature.

▲ When she was a child (pictured right), she looked exactly like her mother.

▲ My parents gave birth to three daughters and a son. She is the eldest in the family, and she should take the initiative to help her younger brothers and sisters.

▲ Like all traditional Chinese families, although parents are strict in discipline, they love their children.

▲ She graduated from UCLA Department of International Social and Political Science, and then participated in the Miss Chinatown Beauty Contest in California in 1999, winning the championship in one fell swoop.

▲ I can still find her name on official website.

▲ This coronation photo is definitely a black history. In fact, her eyes were really not that small at that time.

▲ It is almost as big as this picture, because the fleshy baby face at that time made the eyes smaller.

▲ Her little sister (pictured) also took part in the same competition a few years later, but unfortunately she did not enter the top three.

Melody had already started her acting career in Taiwan Province at that time.

She called this a dream-chasing when she was young. After all, after graduating from a prestigious school, she had a good job opportunity in the United States, but she decided to come back for her dream.

▲ In 2003, Huang Shujun released her first and only album Melody of Love.

▲ Among them, I also collaborated with Fan Yichen on a song "Love in the Adriatic Sea".

▲ Tao Zhe, an ex-boyfriend at the release site, also sent a large basket of flowers and handwritten cards, which triggered a heated discussion in the media.

In those years, Melody’s name was always associated with Tao Zhe, until she played Tian Xin, an English teacher with lovely white eyes in ultimate class in 2005, and then she went to lightning to get married.

▲ In early 2006, she married her husband, Wu Yuqi, who had only known him for half a year.

▲ The two were engaged in Los Angeles and married in Bali, with a diamond ring of 4.8 carats.

▲ Because of the low profile, few wedding photos can be found, and her husband is older than her. There is a 15-year gap between them.

▲ The introducer of the two is Wu Yuqi’s sister Wu Yumei (pictured left), and she is also a famous Kuantai in the city.

▲ Wu Yumei married Xue Zhiwei (pictured left), a wealthy Jewish businessman who came to Taiwan Province for development in his early years. The business of trading companies started by his family was distributed in Southeast Asia, Europe and America.

▲ Wu Yumei, as a lady, attended major events with exaggerated hairstyles and Hermes with special leather, and stood next to her beautiful mixed-race children.

▲ This is Wu Yumei and her mother Wu Baoqin (left), Melody’s mother-in-law. Does the whole family look expensive?

▲ However, in 2013, Wu Yumei died of illness. Four years later, Xue Zhiwei gave up her baldness and shaved her head and married actress Na Tang.

▲ At the wedding scene, Melody stepped on Roger Vivier pearl shoes, holding Bvlgari snakehead bag, and joined hands with her husband to congratulate her ex-brother-in-law, which shows that the two families have a good relationship.

▲ As for rumors on the Internet, Melody’s husband made a fortune by this brother-in-law, and some netizens came forward to refute it, but the language was unclear. Maybe people are really low-key.

In fact, Melody’s own family background is not bad after all.

▲ Graduated from a prestigious school with a double degree, clean family and simple love history.

▲ As the parents of the first generation of immigrants, they have strict standards for their children’s mate selection.

She once mentioned her grandmother’s story in an interview, which was a standard plot of touch of green.

▲ In the 1940s, a rich young lady in Shanghai chose to drift to Taiwan Province in order to be the grandfather of the Air Force and give up everything arranged at home. She lived in a village where the conditions were not as good as before and gave birth to two children. Unexpectedly, just three years after marriage, her husband died in a plane crash. (Source: Weibo @Melody Yin Yue)

▲ The young widowed grandmother didn’t feel depressed because of this. She tried to find a job to bring up her children. She didn’t remarry until the children became adults, immigrated to the United States with her family and enjoyed a new life.

▲ Now grandma is over 90 years old, even if her temples are gray, it is difficult to hide her extravagance. Often living in LA, when she returns to Taiwan Province, she will still go to the Air Force Martyrs Cemetery to see her former lover and present a bunch of flowers to show her homesickness.

No matter what the net worth is in the eyes of outsiders, Melody is definitely living a lady’s life.

▲ The balcony at home faces the mountain and you can see the complete Taipei landmark 101 building.

▲ When going out, there is a helper who is responsible for taking care of the children.

▲ Her standard jewelry is Cartier three-ring diamond ring and large row of diamond fingers, as well as Cartier tiger head ring, large diamond earrings, Cartier full-diamond love bracelet, Hermes watch and bracelet, etc.

She has all kinds of Hermes bags, from entry-level models to crocodile skins.

▲ Whether traveling, videotaping, picking up and dropping off children, participating in activities or taking random street shots, different Hermes bags can always find a suitable way to match.

Melody is 1.7 meters tall, but her head is not particularly small, so sometimes a bad match can easily lead to top-heavy disasters.

▲ For example, in these two pictures, in addition to the shooting angle of the overhead shot, this long coat on the right (or Hermes! To some extent, it shortens the length of the legs, which makes the whole person’s visual proportion strange.

Therefore, how to make the best use of the height advantage and wear it with strengths and weaknesses is the most important thing.

▲ It can be seen that she doesn’t like to wear skirts and high heels except for participating in activities. If you want to wear flat shoes with long skirts, you must choose one that can expose your legs to extend the proportion, otherwise you will wear high heels like the picture below.

▲ Like the picture on the left, flat shoes are pencil skirt’s, which still limits the exertion of legs and makes the whole person look "five-five-body". You should choose high-waist pants to extend the visual length of legs. The simplest white items can also be reused to create new patterns. The same white shirt with skirt is full of femininity, while with fluorescent green wide-leg pants, it is even more ridiculous.

▲ Melody prefers nude colors, which can be worn from spring and summer to autumn and winter. Simply wear black and white colors or jeans. easy chic, brand-name bags are the finishing touch but not the only essential element.

▲ Her style is changeable, and she can be superimposed with a big name, and the lady is full of style.

▲ You can also walk the world simply by zara and H&M.

Melody really loves all kinds of oversize coats and brings them directly to shawls, creating a tough and handsome professional atmosphere, and making the overall shape flexible and not monotonous.

▲ Of course, you can occasionally change your hairstyle and comb two messy and fluffy braided hair to achieve the effect of age reduction.

In fact, I think what she is most suitable for is simple and uncomplicated wearing, which seems to be relaxed and casual, but all of them show their personality in details, not simply adding hard and concave brand names, but fully opening the gas field through matching.

Although she can be called a veritable lady, and all her friends around her are also divinatory, Melody is still very real.

▲ Even in the face of praise, she only modestly said that she had an old face, although the Chanel coat and Hermes bracelet on her body were shouting "It’s really expensive".

▲ She joked that she is a "prostitute" who walks around the market and has to serve her husband, children and dogs.

▲ As long as there is a program where she appears, the ratings will not be bad. Everyone loves her drama, loves her "drama" and "affectation", and nine out of ten comments praise her.

Although she is a lady, the reason why people don’t hate her is because she lives truly enough.

It is a fact that a lady is rich, so she never pretends to be very low-key. In all kinds of ways, she admits her femininity and goes to work, only to give up after a day in a restaurant.

▲ Just because the restaurant manager called her to wash the toilet, this sentence has simply become a voice bag that often watches Kangxi audiences.

▲ She is so popular with the audience. A few words of ABC accent English blurted out are not offensive, but add comedy effect.

▲ The speech is organized, the story is vivid, and the hair is full of American style, which is frank and lovely in her body.

▲ Coupled with echo each other’s reaction, the whole entertainment effect was bursting.

▲ Kang Yong and S commented on her as "expensive" and "naturally annoying", and she accepted it calmly.

She never denied the difficulties and pressures she encountered during pregnancy after marriage.

▲ For nearly four years, Melody didn’t appear in front of the screen but tried to get pregnant, not only because of her husband’s expectations, but also because of her own expectations of being a mother. So that later she wrote a book about her child-seeking experience, and shared it with female friends who had the same troubles, encouraging everyone to relax.

▲ Even if "no one cares about the second child", it is also a spoiled program effect.

▲ She performed the picture that she was awakened by snoring during pregnancy without taboo, which was grounded and lovely.

Because she lives truly, unlike some ladies, she has no sense of security and is full of lies. She gives the impression that she is not a housewife without freedom, and she also has absolutely more time and space after taking care of her family at work.

▲ You can play crazy with like-minded friends.

▲ As for the trivial matters in the daily family, she frankly relies on mommy’s juice to relax and relieve troubles.

As for her husband, she never showed any intention to please or flaunt that she has the upper hand in the marriage relationship.

▲ She will complain exaggeratedly about her husband’s difficulty.

▲ It will also be ridiculous by his so-called "don’t lie" expression.

▲ Of course, there are embarrassing scenes that occasionally drive her crazy, and she never avoids mentioning it. It is an interesting talk about married life.

Regardless of whether these programs are effective or not, at least we can see that the relationship between husband and wife is equal and comfortable, and there is no sense of oppression or desperately trying to prove their powerlessness.

As a fan who used to watch her Facebook live broadcast in the past, for a time, her husband volunteered to act as a humanoid handheld frame. Even if he didn’t tremble all the time, he would insist on accompanying his wife to shoot the live broadcast without complaint. It was really sweet enough.

Second, she is not a puppet at the mercy of others, nor is she a little woman who breathes with admiration. On the contrary, she has her own personal life control and opinion, and she is the top leader inside and outside, and she is capable of convincing people.

▲ You can take a look at her daily schedule, which is full, busy and orderly.

▲ Insist on exercise, never relax your requirements, and maintain almost the same weight all year round.

▲ Before, she challenged herself to take over the location program Mamma Mia, and partnered with Li Yongxian. Although she was afraid of the sun and water, she also achieved good ratings.

▲ Now, even if there are not many announcements, she will regularly update the radio program "Sister Whispers" in the oil pipeline every week.

She is a person who can’t stop and doesn’t want to stop. It is her life creed to keep pushing herself forward.

▲ From 2012 to 2018, she published five books. Of course, I haven’t bought any books, and I’m not sure what the gold content of Taiwan Province’s title of "best-selling author" is. But from an ABC who doesn’t know Chinese to being able to write one book after another, doesn’t it just prove Melody’s process of self-improvement?

▲ In addition to her work, she also has to pick up and drop off her children for piano lessons and stare at their homework.

▲ Education follows family rules, strict discipline, and clear rewards and punishments for children.

▲ Her husband praised her for doing things resolutely, coordinating internal affairs and foreign affairs, and paying attention to "quick and accurate". Look at her expression, it is really a drama queen that is always done in life.

The third is to be honest about the imperfections of life and learn to accept and let go.

▲ No matter how perfect a life is, it has its own troubles. With the appearance of the child, the comments on the child’s appearance often make her feel lost (see if her eldest daughter looks like Melody’s old photos when she was a child, and the ladies are exactly the same).

▲ For some unfriendly voices, Melody didn’t answer back, but wrote a long speech in ins to share his psychological process with you.

▲ My youngest daughter was found to be born with severe myopia (near amblyopia) at the age of three, which once made her exhausted and blamed herself. Fortunately, it was discovered in time, but the subsequent worries were never less than a fraction.

So you see, how difficult it is for a woman to be a daughter, a wife and a mother. All identities should be balanced, and physical strength, brain power and intelligence should be tested in all directions.

▲ Every woman should be her own lady in life and be better to herself.

Fourth, being a lady is not a shopkeeper, but the CEO of a family. It requires people with high emotional intelligence, love and tolerance to complete this complicated work.

Husband is rich, you are a lady, but a lady is not a life of shopping and doing nothing every day.

A lady is a more demanding and complicated life, which requires the victim to understand the lifestyle and code of conduct of another class.

First of all, it’s not to show off one’s wealth, not to tell others what to do. This superficial behavior is the taboo of the industry of ladies. First, it’s rude, and second, it’s lack of style, which is the taboo of many old money families.

Melody is different from those ladies who deliberately show off and wait for others to praise. Melody is more willing to share the sincere feelings between her and her family.

▲ Eat with grandma and grandma.

▲ Take a set of family happiness with mom and dad and the whole family.

▲ No matter how you complain about your husband on the show for the effect, remember to always express your love for your husband.

▲ She said that she is not being stupid but really stupid, but she actually has a super emotional intelligence.

▲ "She has a clear understanding and self-definition of life." (Source: Tubing @ Mrs. Science)

Yes, there are unattractive ladies in this world. Apart from their rich husbands, the greatest feature of these ladies is that they know life very well, know themselves very well, make progress all the time and enjoy their lives.

▲ Melody’s plain state, which is 41 years old, is enough to prove that her happiness in these years is real.

I think this passage deserves everyone’s memory: "You don’t know what will happen tomorrow, but you must listen to your own voice and treat people around you sincerely in the process, so that you can find new inspiration. This is the real purpose of life."

Know how to love yourself, know how to live, manage your life in an orderly way, live truly, and cherish every moment in your life. Whether you are a lady or not, you are quite lovable people.

Recommended: Above: Author: Su Yibai

Original title: "fame and fortune || Is there an annoying lady? What does she look like? 》

Read the original text